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Target
Macrophage migration inhibitory factor
Ligand
BDBM50298027
Substrate
n/a
Meas. Tech.
ChEMBL_585090 (CHEMBL1054356)
IC50
60000±n/a nM
Citation
 Balachandran, S; Rodge, A; Gadekar, PK; Yadav, VN; Kamath, D; Chetrapal-Kunwar, A; Bhatt, P; Srinivasan, S; Sharma, S; Vishwakarma, RA; Dagia, NM Novel derivatives of ISO-1 as potent inhibitors of MIF biological function. Bioorg Med Chem Lett 19:4773-6 (2009) [PubMed]  Article
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50298027
Synonyms:
2-fluoro-4-(5((5-(trifluoromethyl)-1,2,4-oxadiazole-3-yl)methyl)isoxazole-3-yl)phenol | CHEMBL559555
Type:
Small organic molecule
Emp. Form.:
C13H9F4N3O3
Mol. Mass.:
331.2225
SMILES:
Oc1ccc(cc1F)C1=NOC(Cc2noc(n2)C(F)(F)F)C1 |t:9|
Structure:
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