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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50299161
Substrate
n/a
Meas. Tech.
ChEMBL_592083 (CHEMBL1038652)
IC50
5000±n/a nM
Citation
 Bhattarai, BR; Kafle, B; Hwang, JS; Khadka, D; Lee, SM; Kang, JS; Ham, SW; Han, IO; Park, H; Cho, H Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects. Bioorg Med Chem Lett 19:6161-5 (2009) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50299161
Synonyms:
(Z)-5-{3-Bromo-4-[4-(trifluoromethyl)benzyloxy]benzylidene}thiazolidine-2,4-dione | CHEMBL575025
Type:
Small organic molecule
Emp. Form.:
C18H11BrF3NO3S
Mol. Mass.:
458.249
SMILES:
FC(F)(F)c1ccc(COc2ccc(C=C3SC(=O)NC3=O)cc2Br)cc1 |w:14.13|
Structure:
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