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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50299245
Substrate
n/a
Meas. Tech.
ChEMBL_589580 (CHEMBL1051396)
IC50
40±n/a nM
Citation
 Akué-Gédu, R; Rossignol, E; Azzaro, S; Knapp, S; Filippakopoulos, P; Bullock, AN; Bain, J; Cohen, P; Prudhomme, M; Anizon, F; Moreau, P Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. J Med Chem 52:6369-81 (2009) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50299245
Synonyms:
7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL584195 | US8481586, 16
Type:
Small organic molecule
Emp. Form.:
C15H9BrN2O
Mol. Mass.:
313.149
SMILES:
Brc1ccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c2c1
Structure:
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