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Target
Monoglyceride lipase
Ligand
BDBM50300349
Substrate
n/a
Meas. Tech.
ChEMBL_590922 (CHEMBL1045640)
IC50
1700±n/a nM
Citation
 Matuszak, N; Muccioli, GG; Labar, G; Lambert, DM Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem 52:7410-20 (2009) [PubMed]  Article
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50300349
Synonyms:
1,4-bis(malimido)xylene | CHEMBL565711
Type:
Small organic molecule
Emp. Form.:
C16H12N2O4
Mol. Mass.:
296.2775
SMILES:
O=C1C=CC(=O)N1Cc1ccc(CN2C(=O)C=CC2=O)cc1 |c:2,17|
Structure:
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