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Target
Polyphenol oxidase 2
Ligand
BDBM50300459
Substrate
n/a
Meas. Tech.
ChEMBL_592221 (CHEMBL1043163)
IC50
14700±n/a nM
Citation
 Noh, JM; Kwak, SY; Seo, HS; Seo, JH; Kim, BG; Lee, YS Kojic acid-amino acid conjugates as tyrosinase inhibitors. Bioorg Med Chem Lett 19:5586-9 (2009) [PubMed]  Article
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50300459
Synonyms:
CHEMBL573709 | Kojic acid-phenylalanine amide
Type:
Small organic molecule
Emp. Form.:
C16H16N2O6
Mol. Mass.:
332.308
SMILES:
NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1 |r|
Structure:
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