Reaction Details  Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50248442
Substrate
n/a
Meas. Tech.
ChEMBL_588966 (CHEMBL1056161)
EC50
420±n/a nM
Citation
 Iino, T; Sasaki, Y; Bamba, M; Mitsuya, M; Ohno, A; Kamata, K; Hosaka, H; Maruki, H; Futamura, M; Yoshimoto, R; Ohyama, S; Sasaki, K; Chiba, M; Ohtake, N; Nagata, Y; Eiki, J; Nishimura, T Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators. Bioorg Med Chem Lett 19:5531-8 (2009) [PubMed]  Article
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50248442
Synonyms:
2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide | 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide | CHEMBL489514
Type:
Small organic molecule
Emp. Form.:
C14H14N6OS2
Mol. Mass.:
346.431
SMILES:
Cc1csc(NC(=O)c2cc(Sc3nncn3C)ccc2N)n1
Structure:
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