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Target
D-alanyl-D-alanine carboxypeptidase
Ligand
BDBM50300664
Substrate
n/a
Meas. Tech.
ChEMBL_588998 (CHEMBL1056193)
IC50
28000±n/a nM
Citation
 Inglis, SR; Zervosen, A; Woon, EC; Gerards, T; Teller, N; Fischer, DS; Luxen, A; Schofield, CJ Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem 52:6097-106 (2009) [PubMed]  Article
Target
Name:
D-alanyl-D-alanine carboxypeptidase
Synonyms:
DAC_ACTSP | dac
Type:
PROTEIN
Mol. Mass.:
54928.46
Organism:
Actinomadura sp. (strain R39)
Description:
ChEMBL_822544
Residue:
538
Sequence:
MKQSSPEPLRPRRTGGRGGARRAAALVTIPLLPMTLLGASPALADASGARLTELREDIDAILEDPALEGAVSGVVVVDTATGEELYSRDGGEQLLPASNMKLFTAAAALEVLGADHSFGTEVAAESAPGRRGEVQDLYLVGRGDPTLSAEDLDAMAAEVAASGVRTVRGDLYADDTWFDSERLVDDWWPEDEPYAYSAQISALTVAHGERFDTGVTEVSVTPAAEGEPADVDLGAAEGYAELDNRAVTGAAGSANTLVIDRPVGTNTIAVTGSLPADAAPVTALRTVDEPAALAGHLFEEALESNGVTVKGDVGLGGVPADWQDAEVLADHTSAELSEILVPFMKFSNNGHAEMLVKSIGQETAGAGTWDAGLVGVEEALSGLGVDTAGLVLNDGSGLSRGNLVTADTVVDLLGQAGSAPWAQTWSASLPVAGESDPFVGGTLANRMRGTAAEGVVEAKTGTMSGVSALSGYVPGPEGELAFSIVNNGHSGPAPLAVQDAIAVRLAEYAGHQAPEGARMMRGPVQGSGELECSWVQAC
  
Inhibitor
Name:
BDBM50300664
Synonyms:
3-borono-5-(2-phenoxyacetamido)benzoic acid | CHEMBL574622
Type:
Small organic molecule
Emp. Form.:
C15H14BNO6
Mol. Mass.:
315.086
SMILES:
OB(O)c1cc(NC(=O)COc2ccccc2)cc(c1)C(O)=O
Structure:
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