Reaction Details  Report a problem with these data
Target
Casein kinase I isoform delta
Ligand
BDBM50300893
Substrate
n/a
Meas. Tech.
ChEMBL_599899 (CHEMBL1045464)
IC50
11±n/a nM
Citation
 Peifer, C; Abadleh, M; Bischof, J; Hauser, D; Schattel, V; Hirner, H; Knippschild, U; Laufer, S 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem 52:7618-30 (2009) [PubMed]  Article
Target
Name:
Casein kinase I isoform delta
Synonyms:
CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta
Type:
Enzyme
Mol. Mass.:
47342.73
Organism:
Rattus norvegicus (rat)
Description:
Q06486
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50300893
Synonyms:
(E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phenyl)-2-methanesulfinyl-3H-imidazol-4-yl]-pyridin-2-yl)-acrylamide | CHEMBL572006
Type:
Small organic molecule
Emp. Form.:
C26H23FN4O4S
Mol. Mass.:
506.549
SMILES:
COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5|
Structure:
Search PDB for entries with ligand similarity: