Reaction Details  Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50302944
Substrate
n/a
Meas. Tech.
ChEMBL_596154 (CHEMBL1044493)
IC50
370±n/a nM
Citation
 Li, J; Kaoud, TS; Laroche, C; Dalby, KN; Kerwin, SM Synthesis and biological evaluation of p38alpha kinase-targeting dialkynylimidazoles. Bioorg Med Chem Lett 19:6293-7 (2009) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50302944
Synonyms:
2-(4-Fluorophenyl)-3(4-pyridinyl)-5-chloro-7-ethanol-imidazo[1,2-a]-pyridine | CHEMBL584064
Type:
Small organic molecule
Emp. Form.:
C20H15ClFN3O
Mol. Mass.:
367.804
SMILES:
OCCc1cc(Cl)n2c(c(nc2c1)-c1ccc(F)cc1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: