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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50303230
Substrate
n/a
Meas. Tech.
ChEMBL_595122 (CHEMBL1050609)
IC50
34±n/a nM
Citation
 Antczak, C; Veach, DR; Ramirez, CN; Minchenko, MA; Shum, D; Calder, PA; Frattini, MG; Clarkson, B; Djaballah, H Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett 19:6872-6 (2009) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50303230
Synonyms:
3-amino-N-(4-(6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl)propanamide | CHEMBL566635
Type:
Small organic molecule
Emp. Form.:
C23H20Cl2N6O2
Mol. Mass.:
483.35
SMILES:
Cn1c2nc(Nc3ccc(NC(=O)CCN)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(28.74,-40.46,;28.74,-38.92,;27.41,-38.15,;26.08,-38.92,;24.76,-38.15,;23.42,-38.92,;22.09,-38.15,;20.75,-38.93,;19.42,-38.15,;19.42,-36.61,;18.08,-35.84,;16.75,-36.61,;16.75,-38.15,;15.42,-35.84,;14.08,-36.61,;12.75,-35.84,;20.75,-35.84,;22.08,-36.6,;24.74,-36.61,;26.07,-35.84,;27.41,-36.61,;28.74,-35.84,;30.07,-36.6,;31.39,-35.83,;31.39,-34.29,;30.05,-33.53,;32.71,-33.51,;34.06,-34.28,;34.06,-35.82,;32.73,-36.59,;32.74,-38.13,;30.08,-38.15,;31.41,-38.91,)|
Structure:
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