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Target
Signal transducer and activator of transcription 6
Ligand
BDBM50304434
Substrate
n/a
Meas. Tech.
ChEMBL_603163 (CHEMBL1042440)
IC50
12±n/a nM
Citation
 Nagashima, S; Hondo, T; Nagata, H; Ogiyama, T; Maeda, J; Hoshii, H; Kontani, T; Kuromitsu, S; Ohga, K; Orita, M; Ohno, K; Moritomo, A; Shiozuka, K; Furutani, M; Takeuchi, M; Ohta, M; Tsukamoto, S Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors. Bioorg Med Chem 17:6926-36 (2009) [PubMed]  Article
Target
Name:
Signal transducer and activator of transcription 6
Synonyms:
STAT6 | STAT6_HUMAN
Type:
PROTEIN
Mol. Mass.:
94129.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881634
Residue:
847
Sequence:
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
  
Inhibitor
Name:
BDBM50304434
Synonyms:
7-(3,5-Difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-7Hpyrrolo[2,3-d]pyrimidin-2-amine | CHEMBL594344
Type:
Small organic molecule
Emp. Form.:
C23H22F2N6
Mol. Mass.:
420.4578
SMILES:
Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCNCC4)nc23)c1
Structure:
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