Reaction Details  Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50307097
Substrate
n/a
Meas. Tech.
ChEMBL_609369 (CHEMBL1072755)
Ki
2±n/a nM
Citation
 Quan, ML; Pinto, DJ; Rossi, KA; Sheriff, S; Alexander, RS; Amparo, E; Kish, K; Knabb, RM; Luettgen, JM; Morin, P; Smallwood, A; Woerner, FJ; Wexler, RR Phenyltriazolinones as potent factor Xa inhibitors. Bioorg Med Chem Lett 20:1373-7 (2010) [PubMed]  Article
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50307097
Synonyms:
6-(4-(2-((dimethylamino)methyl)-1H-imidazol-1-yl)phenyl)-1-(3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-3a,4,5,6-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7(7aH)-one | CHEMBL592400
Type:
Small organic molecule
Emp. Form.:
C27H24F3N9O2
Mol. Mass.:
563.5338
SMILES:
CN(C)Cc1nccn1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(c1)-c1n[nH]c(=O)[nH]1)C(F)(F)F
Structure:
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