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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM50307233
Substrate
n/a
Meas. Tech.
ChEMBL_610341 (CHEMBL1072073)
IC50
25±n/a nM
Citation
 Roumen, L; Peeters, JW; Emmen, JM; Beugels, IP; Custers, EM; de Gooyer, M; Plate, R; Pieterse, K; Hilbers, PA; Smits, JF; Vekemans, JA; Leysen, D; Ottenheijm, HC; Janssen, HM; Hermans, JJ Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem 53:1712-25 (2010) [PubMed]  Article
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM50307233
Synonyms:
1-(4-Chlorobenzyl)-5-phenyl-1H-imidazole | CHEMBL597101
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2
Mol. Mass.:
268.741
SMILES:
Clc1ccc(Cn2cncc2-c2ccccc2)cc1
Structure:
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