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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50295294
Substrate
n/a
Meas. Tech.
ChEMBL_610434 (CHEMBL1074041)
IC50
690±n/a nM
Citation
 Marcin, LR; Mattson, RJ; Gao, Q; Wu, D; Molski, TF; Mattson, GK; Lodge, NJ Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles. Bioorg Med Chem Lett 20:1027-30 (2010) [PubMed]  Article
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50295294
Synonyms:
(+/-)-trans-3-(2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile | 3-((1S,2S)-2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile | CHEMBL552167 | trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C17H21N3
Mol. Mass.:
267.3687
SMILES:
CN(C)C[C@H]1CCC[C@@H]1c1c[nH]c2ccc(cc12)C#N |r|
Structure:
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