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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50311118
Substrate
n/a
Meas. Tech.
ChEMBL_619838 (CHEMBL1106715)
IC50
28±n/a nM
Citation
 Pasternak, A; Goble, SD; deJesus, RK; Hreniuk, DL; Chung, CC; Tota, MR; Mazur, P; Feighner, SD; Howard, AD; Mills, SG; Yang, L Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists. Bioorg Med Chem Lett 19:6237-40 (2009) [PubMed]  Article
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50311118
Synonyms:
CHEMBL1078982 | N-(4-(2-amino-2-methylpropyl)phenyl)-4-(3-(4-butylphenyl)ureido)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C27H34N4O3S
Mol. Mass.:
494.649
SMILES:
CCCCc1ccc(NC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1
Structure:
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