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Target
Ephrin type-B receptor 3
Ligand
BDBM50311303
Substrate
n/a
Meas. Tech.
ChEMBL_620507 (CHEMBL1107575)
IC50
77±n/a nM
Citation
 Qiao, L; Choi, S; Case, A; Gainer, TG; Seyb, K; Glicksman, MA; Lo, DC; Stein, RL; Cuny, GD Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett 19:6122-6 (2009) [PubMed]  Article
Target
Name:
Ephrin type-B receptor 3
Synonyms:
EPHB3 | EPHB3_HUMAN | ETK2 | Ephrin receptor | Ephrin type-B receptor 3 | Ephrin type-B receptor 3 (EPHB3) | HEK2 | TYRO6 | Tyrosine Kinase EPHB3
Type:
Protein
Mol. Mass.:
110326.17
Organism:
Homo sapiens (Human)
Description:
P54753
Residue:
998
Sequence:
MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMDTKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGTCIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWSEPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV
  
Inhibitor
Name:
BDBM50311303
Synonyms:
CHEMBL1077571 | N-(2-chlorophenyl)-5-(dimethylamino)pyrazolo[1,5-a]pyridine-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C16H15ClN4O
Mol. Mass.:
314.77
SMILES:
CN(C)c1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1
Structure:
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