Reaction Details  Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50311436
Substrate
n/a
Meas. Tech.
ChEMBL_622615 (CHEMBL1109327)
IC50
70600±n/a nM
Citation
 Kumar, A; Maurya, RA; Sharma, S; Ahmad, P; Singh, AB; Bhatia, G; Srivastava, AK Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents. Bioorg Med Chem Lett 19:6447-51 (2009) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50311436
Synonyms:
9-Ethoxymethyl-4-methyl-9-(4-phenyl-piperazin-1-yl-methyl)-8,9-dihydro-pyrano[2,3-f]chromene-2,10-dione | CHEMBL1079387
Type:
Small organic molecule
Emp. Form.:
C27H30N2O5
Mol. Mass.:
462.5375
SMILES:
CCOCC1(CN2CCN(CC2)c2ccccc2)COc2ccc3c(C)cc(=O)oc3c2C1=O
Structure:
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