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Target
Cathepsin S
Ligand
BDBM50312665
Substrate
n/a
Meas. Tech.
ChEMBL_614880 (CHEMBL1115043)
IC50
1620±n/a nM
Citation
 Chou, LC; Chen, CT; Lee, JC; Way, TD; Huang, CH; Huang, SM; Teng, CM; Yamori, T; Wu, TS; Sun, CM; Chien, DS; Qian, K; Morris-Natschke, SL; Lee, KH; Huang, LJ; Kuo, SC Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent. J Med Chem 53:1616-26 (2010) [PubMed]  Article
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50312665
Synonyms:
CHEMBL1088572 | Sodium 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-yl hydrogen phosphate
Type:
Small organic molecule
Emp. Form.:
C16H12FNO6P
Mol. Mass.:
364.2423
SMILES:
OP([O-])(=O)OC1CC(=Nc2cc3OCOc3cc12)c1ccccc1F |c:7|
Structure:
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