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Target
Cyclin-dependent kinase 2
Ligand
BDBM50313661
Substrate
n/a
Meas. Tech.
ChEMBL_614783 (CHEMBL1113302)
IC50
2500±n/a nM
Citation
 Lesuisse, D; Dutruc-Rosset, G; Tiraboschi, G; Dreyer, MK; Maignan, S; Chevalier, A; Halley, F; Bertrand, P; Burgevin, MC; Quarteronet, D; Rooney, T Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett 20:1985-9 (2010) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50313661
Synonyms:
CHEMBL1095040 | N-(6-chloro-5-phenyl-1H-indazol-3-yl)butanamide | N-(6-chloro-5-phenyl-1H-indazol-3-yl)butyramide
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O
Mol. Mass.:
313.781
SMILES:
CCCC(=O)Nc1n[nH]c2cc(Cl)c(cc12)-c1ccccc1
Structure:
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