Reaction Details  Report a problem with these data
Target
Mitogen-activated protein kinase 10
Ligand
BDBM50314146
Substrate
n/a
Meas. Tech.
ChEMBL_624060 (CHEMBL1116946)
IC50
10.9±n/a nM
Citation
 Siddiqui, MA; Reddy, PA Small molecule JNK (c-Jun N-terminal kinase) inhibitors. J Med Chem 53:3005-12 (2010) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM50314146
Synonyms:
(S)-4-(2-(4-fluorophenyl)-5-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-N-propylpyrimidin-2-amine | CHEMBL1094013
Type:
Small organic molecule
Emp. Form.:
C27H28FN5O
Mol. Mass.:
457.5425
SMILES:
CCCNc1nccc(n1)-c1c(nc2CC[C@@H](Cc3ccc(OC)cc3)n12)-c1ccc(F)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: