Target
Sodium/glucose cotransporter 2
Ligand
BDBM50315424
Substrate
n/a
Meas. Tech.
ChEMBL_626547 (CHEMBL1108920)
IC50
2.7±n/a nM
Citation
 Kakinuma, HOi, THashimoto-Tsuchiya, YArai, MKawakita, YFukasawa, YIida, IHagima, NTakeuchi, HChino, YAsami, JOkumura-Kitajima, LIo, FYamamoto, DMiyata, NTakahashi, TUchida, SYamamoto, K (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment. J Med Chem 53:3247-61 (2010) [PubMed]  Article
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:
Protein
Mol. Mass.:
72902.00
Organism:
Homo sapiens (Human)
Description:
P31639
Residue:
672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
  
Inhibitor
Name:
BDBM50315424
Synonyms:
(1S)-1,5-Anhydro-1-[2-methoxy-4-methyl-5-[4-(propan-2-yl)-benzyl]phenyl]-1-thio-D-glucitol | CHEMBL1093778
Type:
Small organic molecule
Emp. Form.:
C24H32O5S
Mol. Mass.:
432.573
SMILES:
COc1cc(C)c(Cc2ccc(cc2)C(C)C)cc1[C@@H]1S[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: