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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50315962
Substrate
n/a
Meas. Tech.
ChEMBL_625738 (CHEMBL1104415)
Ki
8±n/a nM
Citation
 Kurczab, R; Nowak, M; Chilmonczyk, Z; Sylte, I; Bojarski, AJ The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists. Bioorg Med Chem Lett 20:2465-8 (2010) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50315962
Synonyms:
1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methylamino)-3-(2-fluorophenoxy)propan-2-ol | CHEMBL1091933
Type:
Small organic molecule
Emp. Form.:
C18H20FNO4
Mol. Mass.:
333.3541
SMILES:
OC(CNCC1COc2ccccc2O1)COc1ccccc1F
Structure:
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