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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50315966
Substrate
n/a
Meas. Tech.
ChEMBL_625744 (CHEMBL1104421)
Ki
>10000±n/a nM
Citation
 Asada, M; Obitsu, T; Kinoshita, A; Nakai, Y; Nagase, T; Sugimoto, I; Tanaka, M; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists. Bioorg Med Chem Lett 20:2639-43 (2010) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_MOUSE | PGE receptor, EP1 subtype | Prostaglandin E1 | Prostaglandin E2 receptor EP1 subtype | Prostanoid EP1 receptor | Ptger1 | Ptgerep1
Type:
G-protein coupled receptor
Mol. Mass.:
43000.62
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
405
Sequence:
MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM50315966
Synonyms:
3-(4-((3-cyanophenoxy)methyl)-2-(2-(naphthalen-2-yl)ethoxy)phenyl)-N-(3,4-difluorophenylsulfonyl)propanamide | CHEMBL1092431
Type:
Small organic molecule
Emp. Form.:
C35H28F2N2O5S
Mol. Mass.:
626.669
SMILES:
Fc1ccc(cc1F)S(=O)(=O)NC(=O)CCc1ccc(COc2cccc(c2)C#N)cc1OCCc1ccc2ccccc2c1
Structure:
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