Reaction Details  Report a problem with these data
Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50316095
Substrate
n/a
Meas. Tech.
ChEMBL_623471 (CHEMBL1113542)
IC50
>1000±n/a nM
Citation
 Hu, B; Unwalla, RJ; Goljer, I; Jetter, JW; Quinet, EM; Berrodin, TJ; Basso, MD; Feingold, IB; Nilsson, AG; Wilhelmsson, A; Evans, MJ; Wrobel, JE Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist. J Med Chem 53:3296-304 (2010) [PubMed]  Article
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50316095
Synonyms:
CHEMBL1089231 | N-Methyl-4'-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]biphenyl-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C24H18F3N3O
Mol. Mass.:
421.4144
SMILES:
CNC(=O)c1cccc(c1)-c1ccc(cc1)-c1nc2cccc(c2nc1C)C(F)(F)F
Structure:
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