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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50317067
Substrate
n/a
Meas. Tech.
ChEMBL_630344 (CHEMBL1112866)
EC50
4800±n/a nM
Citation
 Steri, R; Rupp, M; Proschak, E; Schroeter, T; Zettl, H; Hansen, K; Schwarz, O; Müller-Kuhrt, L; Müller, KR; Schneider, G; Schubert-Zsilavecz, M Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators. Bioorg Med Chem Lett 20:2920-3 (2010) [PubMed]  Article
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50317067
Synonyms:
3-(isopentyloxycarbonyl)-2,4-diphenylcyclobutanecarboxylic acid | CHEMBL1087588
Type:
Small organic molecule
Emp. Form.:
C23H26O4
Mol. Mass.:
366.4501
SMILES:
CC(C)CCOC(=O)C1C(C(C1c1ccccc1)C(O)=O)c1ccccc1 |(1.84,-28.07,;3.38,-28.07,;4.15,-29.41,;4.16,-26.74,;5.7,-26.75,;6.47,-25.41,;8.01,-25.42,;8.78,-26.75,;8.78,-24.09,;8.78,-22.55,;10.32,-22.55,;10.32,-24.09,;11.65,-24.86,;11.65,-26.4,;12.98,-27.17,;14.32,-26.4,;14.31,-24.85,;12.98,-24.09,;11.65,-21.78,;11.65,-20.24,;12.99,-22.54,;7.47,-21.76,;7.5,-20.22,;6.18,-19.42,;4.83,-20.17,;4.81,-21.72,;6.13,-22.51,)|
Structure:
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