Reaction Details  Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50320524
Substrate
n/a
Meas. Tech.
ChEMBL_638008 (CHEMBL1166729)
IC50
20±n/a nM
Citation
 Bertrand, P Inside HDAC with HDAC inhibitors. Eur J Med Chem 45:2095-116 (2010) [PubMed]  Article
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50320524
Synonyms:
(E)-N-(2-amino-5-(thiophen-2-yl)phenyl)-4-(2-iminoethylideneamino)benzamide | CHEMBL1164671
Type:
Small organic molecule
Emp. Form.:
C19H16N4OS
Mol. Mass.:
348.422
SMILES:
Nc1ccc(cc1NC(=O)c1ccc(cc1)\N=C\C=N)-c1cccs1
Structure:
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