Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50266686
Substrate
n/a
Meas. Tech.
ChEMBL_638634 (CHEMBL1168165)
Ki
42400±n/a nM
Citation
 Alp, C; Ekinci, D; Gültekin, MS; Sentürk, M; Sahin, E; Küfrevioglu, OI A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem 18:4468-74 (2010) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50266686
Synonyms:
1-tosyl-1H-pyrrole | 1-tosyl-pyrrole | CA inhibitor, 13 | CHEMBL508732
Type:
Small organic molecule
Emp. Form.:
C11H11NO2S
Mol. Mass.:
221.276
SMILES:
Cc1ccc(cc1)S(=O)(=O)n1cccc1
Structure:
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