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Target
Carbonic anhydrase 1
Ligand
BDBM50321257
Substrate
n/a
Meas. Tech.
ChEMBL_638633 (CHEMBL1167751)
Ki
510±n/a nM
Citation
 Alp, C; Ekinci, D; Gültekin, MS; Sentürk, M; Sahin, E; Küfrevioglu, OI A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem 18:4468-74 (2010) [PubMed]  Article
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM50321257
Synonyms:
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | CA inhibitor, 16 | CHEMBL1163554
Type:
Small organic molecule
Emp. Form.:
C11H11NO4S
Mol. Mass.:
253.274
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1C(O)C=CC1=O |c:14|
Structure:
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