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Target
UDP-glucose 4-epimerase
Ligand
BDBM50322664
Substrate
n/a
Meas. Tech.
ChEMBL_642050 (CHEMBL1176082)
IC50
5600±n/a nM
Citation
 Durrant, JD; Urbaniak, MD; Ferguson, MA; McCammon, JA Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness. J Med Chem 53:5025-32 (2010) [PubMed]  Article
Target
Name:
UDP-glucose 4-epimerase
Synonyms:
UDP-galactose 4-epimerase
Type:
PROTEIN
Mol. Mass.:
43523.37
Organism:
Trypanosoma brucei
Description:
ChEMBL_642050
Residue:
395
Sequence:
MRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQRLTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYDTLEAIMETSWKFQRTHPNGYASQENGTPGGRTTKL
  
Inhibitor
Name:
BDBM50322664
Synonyms:
2'-(9-ethyl-9H-carbazol-3-ylcarbamoyl)biphenyl-2-carboxylic acid | CHEMBL1172912
Type:
Small organic molecule
Emp. Form.:
C28H22N2O3
Mol. Mass.:
434.4859
SMILES:
CCn1c2ccccc2c2cc(NC(=O)c3ccccc3-c3ccccc3C(O)=O)ccc12
Structure:
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