Reaction Details  Report a problem with these data
Target
Alpha-1A adrenergic receptor
Ligand
BDBM50323401
Substrate
n/a
Meas. Tech.
ChEMBL_644068 (CHEMBL1211967)
Ki
76±n/a nM
Citation
 Li, JJ; Shanmugasundaram, V; Reddy, S; Fleischer, LL; Wang, Z; Smith, Y; Harter, WG; Yue, WS; Swaroop, M; Li, L; Ji, CX; Dettling, D; Osak, B; Fitzgerald, LR; Conradi, R Smoothened antagonists for hair inhibition. Bioorg Med Chem Lett 20:4932-5 (2010) [PubMed]  Article
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50323401
Synonyms:
4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)methyl)-5-methyl-1-phenyl-1H-pyrazole | CHEMBL1209158
Type:
Small organic molecule
Emp. Form.:
C21H22FN3O2
Mol. Mass.:
367.4167
SMILES:
COc1cccc(F)c1OC1CN(Cc2cnn(c2C)-c2ccccc2)C1
Structure:
Search PDB for entries with ligand similarity: