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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50326904
Substrate
n/a
Meas. Tech.
ChEMBL_663241 (CHEMBL1251348)
IC50
0.9±n/a nM
Citation
 Wu, B; Wang, HL; Pettus, L; Wurz, RP; Doherty, EM; Henkle, B; McBride, HJ; Saris, CJ; Wong, LM; Plant, MH; Sherman, L; Lee, MR; Hsieh, F; Tasker, AS Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors. J Med Chem 53:6398-411 (2010) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50326904
Synonyms:
8-(2,4-Difluorophenyl)-3-(2,4-difluorophenylamino)-1-methylpyrido[3,2-d]pyridazin-2(1H)-one | CHEMBL1254075
Type:
Small organic molecule
Emp. Form.:
C20H12F4N4O
Mol. Mass.:
400.3291
SMILES:
Cn1c2c(nncc2cc(Nc2ccc(F)cc2F)c1=O)-c1ccc(F)cc1F
Structure:
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