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Target
LIM domain kinase 2
Ligand
BDBM50327390
Substrate
n/a
Meas. Tech.
ChEMBL_664472 (CHEMBL1259854)
IC50
362±n/a nM
Citation
 Lin, S; Wrobleski, ST; Hynes, J; Pitt, S; Zhang, R; Fan, Y; Doweyko, AM; Kish, KF; Sack, JS; Malley, MF; Kiefer, SE; Newitt, JA; McKinnon, M; Trzaskos, J; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38a MAP kinase inhibitors. Bioorg Med Chem Lett 20:5864-8 (2010) [PubMed]  Article
Target
Name:
LIM domain kinase 2
Synonyms:
LIMK2 | LIMK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
72238.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514398
Residue:
638
Sequence:
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
  
Inhibitor
Name:
BDBM50327390
Synonyms:
5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-yl)-N-isopropylthiazol-2-amine | CHEMBL1258633
Type:
Small organic molecule
Emp. Form.:
C21H18ClN5S
Mol. Mass.:
407.919
SMILES:
CC(C)Nc1ncc(s1)-c1cc(nc(n1)-c1ccccn1)-c1ccccc1Cl
Structure:
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