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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50328749
Substrate
n/a
Meas. Tech.
ChEMBL_675347 (CHEMBL1273384)
IC50
1458000±n/a nM
Citation
 Feng, Y; Li, M; Wang, B; Zheng, YG Discovery and mechanistic study of a class of protein arginine methylation inhibitors. J Med Chem 53:6028-39 (2010) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50328749
Synonyms:
3-hydroxy-4-(3-nitrophenylsulfonamido)naphthalene-1-sulfonate | CHEMBL1269029
Type:
Small organic molecule
Emp. Form.:
C16H11N2O8S2
Mol. Mass.:
423.398
SMILES:
Oc1cc(c2ccccc2c1NS(=O)(=O)c1cccc(c1)[N+]([O-])=O)S([O-])(=O)=O
Structure:
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