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Target
Renin
Ligand
BDBM50330345
Substrate
n/a
Meas. Tech.
ChEMBL_685577 (CHEMBL1285355)
IC50
0.039±n/a nM
Citation
 Webb, RL; Schiering, N; Sedrani, R; Maibaum, J Direct renin inhibitors as a new therapy for hypertension. J Med Chem 53:7490-520 (2010) [PubMed]  Article
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50330345
Synonyms:
CHEMBL1276275 | N-(2-(7-(((3R,4R)-4-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl)piperidin-3-yloxy)methyl)-3,4-dihydroquinolin-1(2H)-yl)ethyl)acetamide | Ro-66-1168
Type:
Small organic molecule
Emp. Form.:
C36H47N3O5
Mol. Mass.:
601.7755
SMILES:
COc1ccccc1COCCCOc1ccc(cc1)[C@H]1CCNC[C@@H]1OCc1ccc2CCCN(CCNC(C)=O)c2c1 |r|
Structure:
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