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Target
Acyl-CoA desaturase 1
Ligand
BDBM50330385
Substrate
n/a
Meas. Tech.
ChEMBL_683827 (CHEMBL1285218)
IC50
10±n/a nM
Citation
 Uto, Y; Ueno, Y; Kiyotsuka, Y; Miyazawa, Y; Kurata, H; Ogata, T; Yamada, M; Deguchi, T; Konishi, M; Takagi, T; Wakimoto, S; Ohsumi, J Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs. Eur J Med Chem 45:4788-96 (2010) [PubMed]  Article
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50330385
Synonyms:
6-(3,4-Dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-N-(2-pyridin-3-ylethyl)pyridazine-3-carboxamide | CHEMBL1276721
Type:
Small organic molecule
Emp. Form.:
C24H25N5O2
Mol. Mass.:
415.4876
SMILES:
O=C(NCc1cccnc1)c1ccc(nn1)N1CCC2(CC1)CCc1ccccc1O2
Structure:
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