Reaction Details  Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50193584
Substrate
n/a
Meas. Tech.
ChEMBL_685059 (CHEMBL1286675)
Ki
7560±n/a nM
Citation
 Giovannoni, MP; Vergelli, C; Cilibrizzi, A; Crocetti, L; Biancalani, C; Graziano, A; Dal Piaz, V; Loza, MI; Cadavid, MI; Díaz, JL; Gavaldà, A Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands. Bioorg Med Chem 18:7890-9 (2010) [PubMed]  Article
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50193584
Synonyms:
3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-one | CHEMBL213425
Type:
Small organic molecule
Emp. Form.:
C22H17N5O
Mol. Mass.:
367.4033
SMILES:
Cc1nn(Cc2ccccc2)c(=O)c2ncn3nc(cc3c12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: