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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50331277
Substrate
n/a
Meas. Tech.
ChEMBL_686608 (CHEMBL1292403)
IC50
5940±n/a nM
Citation
 Herdemann, M; Heit, I; Bosch, FU; Quintini, G; Scheipers, C; Weber, A Identification of potent ITK inhibitors through focused compound library design including structural information. Bioorg Med Chem Lett 20:6998-7003 (2010) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50331277
Synonyms:
3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine | CHEMBL1288582
Type:
Small organic molecule
Emp. Form.:
C15H12N4O
Mol. Mass.:
264.282
SMILES:
COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Structure:
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