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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50332149
Substrate
n/a
Meas. Tech.
ChEMBL_687950 (CHEMBL1291622)
IC50
5±n/a nM
Citation
 Zhao, L; Zhang, Y; Dai, C; Guzi, T; Wiswell, D; Seghezzi, W; Parry, D; Fischmann, T; Siddiqui, MA Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors. Bioorg Med Chem Lett 20:7216-21 (2010) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50332149
Synonyms:
(S)-4-(piperidin-3-ylamino)-2-(4-(trifluoromethyl)phenyl)thieno[3,2-c]pyridine-7-carboxamide | CHEMBL1288132
Type:
Small organic molecule
Emp. Form.:
C20H19F3N4OS
Mol. Mass.:
420.451
SMILES:
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(sc12)-c1ccc(cc1)C(F)(F)F |r|
Structure:
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