Reaction Details  Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50332892
Substrate
n/a
Meas. Tech.
ChEMBL_694006 (CHEMBL1636582)
Ki
121.5±n/a nM
Citation
 Silvestri, R; Ligresti, A; La Regina, G; Piscitelli, F; Gatti, V; Lavecchia, A; Brizzi, A; Pasquini, S; Allarà, M; Fantini, N; Carai, MA; Bigogno, C; Rozio, MG; Sinisi, R; Novellino, E; Colombo, G; Di Marzo, V; Dondio, G; Corelli, F Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands. Eur J Med Chem 45:5878-86 (2010) [PubMed]  Article
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50332892
Synonyms:
1-(2,4-Dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-N-tert-pentyl-1H-pyrazole-3-carboxamide | CHEMBL1631298
Type:
Small organic molecule
Emp. Form.:
C22H26Cl2N4O
Mol. Mass.:
433.374
SMILES:
CCC(C)(C)NC(=O)c1nn(c(c1C)-n1c(C)ccc1C)-c1ccc(Cl)cc1Cl |(13.97,-1.89,;13.2,-3.22,;11.66,-3.23,;10.32,-3.98,;11.65,-4.76,;10.89,-1.9,;9.34,-1.9,;8.58,-.58,;8.56,-3.25,;8.98,-4.72,;7.71,-5.58,;6.51,-4.61,;7.05,-3.18,;6.22,-1.87,;4.97,-4.7,;4.05,-3.45,;4.51,-1.98,;2.61,-3.93,;2.6,-5.46,;4.08,-5.93,;4.55,-7.4,;7.7,-7.12,;6.38,-7.89,;6.37,-9.44,;7.71,-10.21,;7.71,-11.75,;9.04,-9.44,;9.04,-7.89,;10.39,-7.1,)|
Structure:
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