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Target
Bombesin receptor subtype-3
Ligand
BDBM50314976
Substrate
n/a
Meas. Tech.
ChEMBL_718487 (CHEMBL1680282)
EC50
66±n/a nM
Citation
 Sebhat, IK; Franklin, C; Lo, MM; Chen, D; Jewell, JP; Miller, R; Pang, J; Palyha, O; Kan, Y; Kelly, TM; Guan, XM; Marsh, DJ; Kosinski, JA; Metzger, JM; Lyons, K; Dragovic, J; Guzzo, PR; Henderson, AJ; Reitman, ML; Nargund, RP; Wyvratt, MJ Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity ACS Med Chem Lett 2:43-47 (2011) [PubMed]  Article
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50314976
Synonyms:
2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-5-fluoropyridine | CHEMBL1093184
Type:
Small organic molecule
Emp. Form.:
C22H26FN3
Mol. Mass.:
351.4603
SMILES:
CCC(C)(C)Cc1cnc(CCc2ccc(cc2)-c2ccc(F)cn2)[nH]1
Structure:
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