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Target
Gamma-aminobutyric acid receptor subunit alpha-2
Ligand
BDBM50337275
Substrate
n/a
Meas. Tech.
ChEMBL_726366 (CHEMBL1687498)
IC50
185±n/a nM
Citation
 Hintermann, S; Hurth, K; Nozulak, J; Tintelnot-Blomley, M; Aichholz, R; Blanz, J; Kaupmann, K; Mosbacher, J Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor. Bioorg Med Chem Lett 21:1523-6 (2011) [PubMed]  Article
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-2
Synonyms:
GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)
Type:
Protein
Mol. Mass.:
51338.78
Organism:
Homo sapiens (Human)
Description:
P47869
Residue:
451
Sequence:
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
  
Inhibitor
Name:
BDBM50337275
Synonyms:
2-(4-chlorophenyl)-3-(cyclopropylmethoxy)-6,7,8,9-tetrahydro-2H-pyrazolo[4,3-c]quinoline | CHEMBL1681900
Type:
Small organic molecule
Emp. Form.:
C20H20ClN3O
Mol. Mass.:
353.845
SMILES:
Clc1ccc(cc1)-n1nc2c3CCCCc3ncc2c1OCC1CC1
Structure:
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