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Target
Coagulation factor X
Ligand
BDBM50338684
Substrate
n/a
Meas. Tech.
ChEMBL_726871 (CHEMBL1686577)
Ki
15±n/a nM
Citation
 Young, RJ; Adams, C; Blows, M; Brown, D; Burns-Kurtis, CL; Chan, C; Chaudry, L; Convery, MA; Davies, DE; Exall, AM; Foster, G; Harling, JD; Hortense, E; Irvine, S; Irving, WR; Jackson, S; Kleanthous, S; Pateman, AJ; Patikis, AN; Roethka, TJ; Senger, S; Stelman, GJ; Toomey, JR; West, RI; Whittaker, C; Zhou, P; Watson, NS Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs. Bioorg Med Chem Lett 21:1582-7 (2011) [PubMed]  Article
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50338684
Synonyms:
(R/S)-(E)-2-(5-chlorothiophen-2-yl)-N-((3S)-1-(2-fluoro-4-(1-methylpyrrolidin-2-yl)phenyl)-2-oxopyrrolidin-3-yl)ethenesulfonamide | CHEMBL1684186
Type:
Small organic molecule
Emp. Form.:
C21H23ClFN3O3S2
Mol. Mass.:
484.007
SMILES:
CN1CCCC1c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 |r|
Structure:
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