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Target
Melanocortin receptor 3
Ligand
BDBM50340462
Substrate
n/a
Meas. Tech.
ChEMBL_741140 (CHEMBL1764411)
IC50
650±n/a nM
Citation
 Hong, Q; Bakshi, RK; Palucki, BL; Park, MK; Ye, Z; He, S; Pollard, PG; Sebhat, IK; Liu, J; Guo, L; Cashen, DE; Martin, WJ; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Strack, AM; Fong, TM; MacIntyre, DE; Wyvratt, MJ; Nargund, RP Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett 21:2330-4 (2011) [PubMed]  Article
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50340462
Synonyms:
CHEMBL1761870 | Cis-(3S,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl)-3-(4-fluorophenyl)-1-oxopropan-2-yl)-3,5-dimethylpiperazine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C32H50FN5O3
Mol. Mass.:
571.7695
SMILES:
C[C@H]1CN(C[C@@H](C)N1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C |r|
Structure:
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