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Target
Tyrosinase
Ligand
BDBM50263336
Substrate
n/a
Meas. Tech.
ChEMBL_740266 (CHEMBL1764166)
IC50
370±n/a nM
Citation
 Tajima, R; Oozeki, H; Muraoka, S; Tanaka, S; Motegi, Y; Nihei, H; Yamada, Y; Masuoka, N; Nihei, K Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem 46:1374-81 (2011) [PubMed]  Article
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50263336
Synonyms:
4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol | CHEMBL499124 | US9682910, 4,4'-(ethane-1,2diyl)dibenzene-1,3-diol (16)
Type:
Small organic molecule
Emp. Form.:
C14H14O4
Mol. Mass.:
246.2586
SMILES:
Oc1ccc(CCc2ccc(O)cc2O)c(O)c1
Structure:
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