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Target
Transcription factor Jun
Ligand
BDBM50341205
Substrate
n/a
Meas. Tech.
ChEMBL_741821 (CHEMBL1769966)
IC50
1500±n/a nM
Citation
 Devkota, KP; Ratnayake, R; Colburn, NH; Wilson, JA; Henrich, CJ; McMahon, JB; Beutler, JA Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius. J Nat Prod 74:374-7 (2011) [PubMed]  Article
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50341205
Synonyms:
CHEMBL1765574 | nagilactone F
Type:
Small organic molecule
Emp. Form.:
C19H24O4
Mol. Mass.:
316.3915
SMILES:
CC(C)[C@H]1OC(=O)C=C2C1=C[C@H]1OC(=O)[C@@]3(C)CCC[C@@]2(C)[C@@H]13 |r,c:7,t:10|
Structure:
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