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Target
Transcription factor Jun
Ligand
BDBM50341206
Substrate
n/a
Meas. Tech.
ChEMBL_741821 (CHEMBL1769966)
IC50
4000±n/a nM
Citation
 Devkota, KP; Ratnayake, R; Colburn, NH; Wilson, JA; Henrich, CJ; McMahon, JB; Beutler, JA Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius. J Nat Prod 74:374-7 (2011) [PubMed]  Article
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50341206
Synonyms:
CHEMBL1765575 | inumakilactone
Type:
Small organic molecule
Emp. Form.:
C19H22O7
Mol. Mass.:
362.3738
SMILES:
CC(C)[C@H]1OC(=O)C=C2[C@@]11O[C@@H]1[C@H]1OC(=O)[C@]3(C)[C@H]1[C@]2(C)[C@@H]1O[C@@H]1[C@@H]3O |r,c:7|
Structure:
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