Reaction Details  Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50341447
Substrate
n/a
Meas. Tech.
ChEMBL_741670 (CHEMBL1769662)
IC50
10000±n/a nM
Citation
 Procopiou, PA; Browning, C; Buckley, JM; Clark, KL; Fechner, L; Gore, PM; Hancock, AP; Hodgson, ST; Holmes, DS; Kranz, M; Looker, BE; Morriss, KM; Parton, DL; Russell, LJ; Slack, RJ; Sollis, SL; Vile, S; Watts, CJ The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis. J Med Chem 54:2183-95 (2011) [PubMed]  Article
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50341447
Synonyms:
4-[(4-Chlorophenyl)methyl]-2-({(2R)-1-[4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]-2-pyrrolidinyl}methyl)-1(2H)-phthalazinone | CHEMBL1767164
Type:
Small organic molecule
Emp. Form.:
C39H49ClN4O2
Mol. Mass.:
641.285
SMILES:
Clc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: