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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50341673
Substrate
n/a
Meas. Tech.
ChEMBL_743261 (CHEMBL1769015)
IC50
13.03±n/a nM
Citation
 Desideri, N; Bolasco, A; Fioravanti, R; Monaco, LP; Orallo, F; Yáñez, M; Ortuso, F; Alcaro, S Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties. J Med Chem 54:2155-64 (2011) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50341673
Synonyms:
(E)-5,7-dichloro-3-(4-chlorobenzylidene)chroman-4-one | CHEMBL1766551
Type:
Small organic molecule
Emp. Form.:
C16H9Cl3O2
Mol. Mass.:
339.6
SMILES:
Clc1ccc(\C=C2/COc3cc(Cl)cc(Cl)c3C2=O)cc1
Structure:
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