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Target
Histone deacetylase 3
Ligand
BDBM50341842
Substrate
n/a
Meas. Tech.
ChEMBL_743699 (CHEMBL1767468)
IC50
10600±n/a nM
Citation
 Botta, CB; Cabri, W; Cini, E; De Cesare, L; Fattorusso, C; Giannini, G; Persico, M; Petrella, A; Rondinelli, F; Rodriquez, M; Russo, A; Taddei, M Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation. J Med Chem 54:2165-82 (2011) [PubMed]  Article
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50341842
Synonyms:
(S)-2-(Hydroxyimino)-8-((4-methoxybenzyl)amino)-N1methyl-N9-phenylnonanediamide | CHEMBL1767046
Type:
Small organic molecule
Emp. Form.:
C24H32N4O4
Mol. Mass.:
440.5353
SMILES:
CNC(=O)C(CCCCC[C@H](NCc1ccc(OC)cc1)C(=O)Nc1ccccc1)N=O |r|
Structure:
Search PDB for entries with ligand similarity: