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Target
Histone deacetylase 11
Ligand
BDBM50341854
Substrate
n/a
Meas. Tech.
ChEMBL_743707 (CHEMBL1767521)
IC50
34100±n/a nM
Citation
 Botta, CB; Cabri, W; Cini, E; De Cesare, L; Fattorusso, C; Giannini, G; Persico, M; Petrella, A; Rondinelli, F; Rodriquez, M; Russo, A; Taddei, M Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation. J Med Chem 54:2165-82 (2011) [PubMed]  Article
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50341854
Synonyms:
CHEMBL1767039 | N9-(3-(6-Chloropyridin-3-yl)phenyl)-2-(hydroxyimino)-N1-methylnonanediamide
Type:
Small organic molecule
Emp. Form.:
C21H25ClN4O3
Mol. Mass.:
416.901
SMILES:
CNC(=O)C(CCCCCCC(=O)Nc1cccc(c1)-c1ccc(Cl)nc1)N=O
Structure:
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